Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 3/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.87 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | MGLL | Q99685 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10720943 | 0.90 | PHGDH (0.81) | PHGDHAKR1C3SMN1; SMN2PKMHPGD | |
| SCHEMBL3455453 | 0.88 | PHGDH (0.77) | PHGDHAKR1C3SMN1; SMN2PKMHPGD | |
| SCHEMBL3937303 | 0.88 | EPHX2 (0.77) | PHGDHAKR1C3SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL9585721 | 0.86 | POLB (0.81) | PHGDHAKR1C3HPGDALDH1A1HSD17B10 | |
| SCHEMBL10722382 | 0.86 | POLB (0.81) | PHGDHAKR1C3HPGDALDH1A1HSD17B10 | |
| SCHEMBL28296651 | 0.85 | HPGD (0.86) | PHGDHAKR1C3SMN1; SMN2PKMHPGD | |
| SCHEMBL19423879 | 0.84 | PHGDH (0.71) | PHGDHAKR1C3SMN1; SMN2PKMHPGD | |
| (4-Chlorophenyl)(Morpholino)Methanone SCHEMBL27532341 | 0.83 | PHGDH (0.69) | PHGDHAKR1C3SMN1; SMN2PKMHPGD | |
| SCHEMBL3455455 | 0.83 | SMN1; SMN2 (1.00) | PHGDHAKR1C3SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL2199279 | 0.83 | PHGDH (0.71) | PHGDHAKR1C3SMN1; SMN2PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119504653-A | Carboxylic acid amidation method | 国网安徽省电力有限公司电力科学研究院 | 2025-02-25 | — | — | CN | disclosed |
| CN-108658816-B | N-aryl amidine substituted trifluoroethyl sulfide derivatives useful as acaricides and insecticides | 拜尔农作物科学股份公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-3395171-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | Bayer CropScience Aktiengesellschaft (DE) | 2018-10-31 | — | — | EP | disclosed |
| US-10051861-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | BAYER CROPSCIENCE AG (DE) | 2018-08-21 | — | — | US | disclosed |
| EP-2793578-B1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2018-06-06 | — | — | EP | disclosed |
| EP-2793578-B1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYLSULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2018-06-06 | — | — | EP | disclosed |
| US-9642363-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | BAYER CROPSCIENCE AG (DE) | 2017-05-09 | — | — | US | disclosed |
| US-9642363-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | BAYER CROPSCIENCE AG (DE) | 2017-05-09 | — | — | US | disclosed |
| US-9642363-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | BAYER CROPSCIENCE AG (DE) | 2017-05-09 | — | — | US | disclosed |
| US-20170057914-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG | 2017-03-02 | — | — | US | disclosed |
| US-20140315898-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2014-10-23 | — | — | US | disclosed |
| US-20140315898-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2014-10-23 | — | — | US | disclosed |
| US-20140315898-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2014-10-23 | — | — | US | disclosed |
| WO-2013092350-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | BAYER CROPSCIENCE AG (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-1352731-A2 | Method of orienting polymer molecules | MISSISSIPPI POLYMER TECHNOLOGIES, INC. (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0629217-B1 | RIGID-ROD POLYMERS | MISSISSIPPI POLYMER TECHNOLOGI (US) | 2003-05-07 | — | — | EP | disclosed |
| US-4988822-A | Intermediates for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1991-01-29 | — | — | US | disclosed |
| US-4873340-A | Process for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-A]pyrrole-1,1-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0053021-B1 | PROCESS FOR 5-AROYLATION OF 1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1-CARBOXYLIC ESTERS AND NITRILES | SYNTEX (U.S.A.) INC. (US) | 1985-05-02 | — | — | EP | disclosed |
| EP-0053021-A2 | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1-carboxylic esters and nitriles | SYNTEX (U.S.A.) INC. (US) | 1982-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315898-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | AFF4, ARSA, AFF1 | PHGDH 4286/4885AKR1C3 447/4885SMN1; SMN2 711/4885 |
| US-10051861-B2 | N-arylamidine-substituted trifluoroethyl sulfide derivatives as acaricides and insecticides | AFF4, AFF1, ARSA | PHGDH 4264/4885AKR1C3 406/4885SMN1; SMN2 697/4885 |
| US-20170057914-A1 | N-ARYLAMIDINE-SUBSTITUTED TRIFLUOROETHYL SULFIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES | AFF4, ARSA, AFF1 | PHGDH 4286/4885AKR1C3 447/4885SMN1; SMN2 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.