Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.86 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360873 | 0.93 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL361102 | 0.93 | BACE1 (1.00) | BACE1BACE2 | |
| Hydrochloric Acid SCHEMBL361858 | 0.92 | BACE1 (0.98) | BACE1BACE2 | |
| SCHEMBL361485 | 0.91 | BACE1 (1.00) | BACE1BACE2APP | |
| SCHEMBL14135735 | 0.89 | BACE1 (0.81) | BACE1BACE2 | |
| SCHEMBL361710 | 0.89 | BACE1 (1.00) | BACE1 | |
| SCHEMBL1910632 | 0.85 | BACE1 (0.86) | BACE1APP | |
| SCHEMBL362498 | 0.85 | BACE1 (1.00) | BACE1 | |
| SCHEMBL363629 | 0.84 | BACE1 (1.00) | BACE1BACE2 | |
| SCHEMBL360383 | 0.84 | BACE1 (1.00) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009943-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |