Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.64 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.64 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940538 | 0.89 | CYP2C9 (0.58) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL1880539 | 0.86 | CYP2C9 (0.78) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL17237478 | 0.83 | CYP2C9 (0.54) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL1182080 | 0.83 | IGF1R (0.56) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL1181947 | 0.81 | CYP2C9 (0.69) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL1877266 | 0.80 | CYP2C9 (0.55) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| Etravirine SCHEMBL52691 | 0.79 | CYP2C9 (1.00) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| Etravirine SCHEMBL3219153 | 0.78 | CYP2C9 (0.98) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| Etravirine SCHEMBL28640238 | 0.78 | CYP2C9 (0.98) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 | |
| SCHEMBL1183774 | 0.78 | IGF1R (0.55) | CYP2C9CYP2C19CYP2D6KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030114472-A1 | Viricides | JANSSEN PHARMACEUTICA, N.V. (BE) | 2003-06-19 | — | — | US | claimed |
| EP-1002795-B1 | HIV Replication inhibiting pyrimidines | JANSSEN PHARMACEUTICA NV (BE) | 2003-03-05 | — | — | EP | claimed |
| EP-1002795-A1 | HIV Replication inhibiting pyrimidines | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-24 | — | — | EP | claimed |
| WO-2000027825-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114472-A1 | Viricides | ZC3HAV1, ZC3HAV1L, POLR2H | CYP2C9 1103/4885CYP2C19 2432/4885CYP2D6 97/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.