Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.61 |
| ▸ | CDK4 | P11802 | 12/20 | 0.60 |
| ▸ | CCND1 | P24385 | 12/20 | 0.60 |
| ▸ | CCND2 | P30279 | 12/20 | 0.60 |
| ▸ | CCND3 | P30281 | 12/20 | 0.60 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.55 |
| ▸ | MARK3 | P27448 | 1/20 | 0.55 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.55 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.55 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.55 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940707 | 0.85 | CDK4 (0.62) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL6942982 | 0.85 | CDK4 (0.72) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL6938652 | 0.84 | CDK4 (0.82) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL7071401 | 0.84 | CDK4 (0.72) | EGFRCDK4CCND1CCND2CCND3 | |
| Trifluoroacetic Acid SCHEMBL7074140 | 0.82 | CDK4 (0.75) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL30878529 | 0.76 | CDK4 (0.55) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL29576158 | 0.76 | SYK (0.60) | EGFRCDK4CCND1CDK1CCNB1 | |
| SCHEMBL15752580 | 0.76 | EGFR (1.00) | EGFR | |
| SCHEMBL30878808 | 0.75 | CCND3 (0.62) | EGFRCDK4CCND1CCND2CCND3 | |
| SCHEMBL6939302 | 0.75 | CCND3 (0.58) | EGFRCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |