Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R known ✓ | P32245 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL29170764 | 0.94 | KMT2A (0.59) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL14343057 | 0.94 | KMT2A (0.59) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL29290494 | 0.91 | MEN1 (0.57) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL27733277 | 0.91 | MEN1 (0.57) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL28252800 | 0.91 | MEN1 (0.57) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL8540399 | 0.91 | MEN1 (0.57) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL31201831 | 0.88 | KMT2A (0.52) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL28607271 | 0.85 | KMT2A (0.49) | MEN1KMT2ATDP1CHRM2MAOA | |
| Acetic Acid SCHEMBL28375367 | 0.85 | KMT2A (0.49) | MEN1KMT2ATDP1CHRM2MAOA | |
| SCHEMBL4909407 | 0.83 | TDP1 (0.74) | MEN1KMT2ATDP1CHRM2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327454-A2 | Method of treatment with medical agents | Mitra Medical Technology AB (SE) | 2003-07-16 | — | — | EP | disclosed |
| EP-0436717-B1 | SYSTEM FOR USE IN A METHOD OF THERAPEUTIC OR DIAGNOSTIC TREATMENT | MITRA MEDICAL TECHNOLOGY AB (SE) | 2003-02-26 | — | — | EP | disclosed |
| US-6046225-A | Method of treatment with medical agents | COBE LABORATORIES, INC. (US) | 2000-04-04 | — | — | US | disclosed |
| US-5474772-A | Method of treatment with medical agents | COBE LABORATORIES, INC. (US) | 1995-12-12 | — | — | US | disclosed |
| EP-0436717-A4 | METHOD OF TREATMENT WITH MEDICAL AGENTS | — | 1993-03-24 | — | — | EP | disclosed |
| EP-0436717-A1 | METHOD OF TREATMENT WITH MEDICAL AGENTS | COBE LABORATORIES, INC. (US) | 1991-07-17 | — | — | EP | disclosed |
| WO-1991001749-A1 | METHOD OF TREATMENT WITH MEDICAL AGENTS | COBE LABORATORIES, INC. (US) | 1991-02-21 | — | — | WO | disclosed |