Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 8/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19050214 | 0.82 | IDO1 (0.57) | HRH4HRH3IDO1F2 | |
| SCHEMBL693232 | 0.82 | HRH4 (0.40) | HRH4HRH3IDO1CACNA1HTBXAS1 | |
| SCHEMBL6587779 | 0.82 | F2 (0.51) | F2 | |
| SCHEMBL8812007 | 0.78 | HRH4 (0.47) | HRH4HRH3IDO1MPOF2 | |
| SCHEMBL6620032 | 0.76 | DAO (0.43) | IDO1MPOF2 | |
| SCHEMBL22128280 | 0.75 | IDO1 (0.48) | HRH4HRH3IDO1CACNA1HMMP2 | |
| SCHEMBL6616428 | 0.73 | HRH3 (0.43) | HRH4HRH3IDO1F2 | |
| SCHEMBL694604 | 0.72 | HRH4 (0.39) | HRH4HRH3IDO1CACNA1HTBXAS1 | |
| SCHEMBL694356 | 0.72 | CYP19A1 (0.68) | — | |
| SCHEMBL26703893 | 0.72 | F2 (0.50) | HRH3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |
| EP-2421851-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124102-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |