SCHEMBL6941108

SCHEMBL6941108

CCc1cc(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCNCC4)cc3)ncc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 20/20 1.00
CCND1 P24385 18/20 1.00
CCND2 P30279 16/20 1.00
CCND3 P30281 16/20 1.00
FGFR1 P11362 5/20 0.82
FGFR2 P21802 5/20 0.82
FGFR4 P22455 5/20 0.82
FGFR3 P22607 5/20 0.82
NUAK1 O60285 2/20 0.82
CCNA2 P20248 7/20 0.74
CDK2 P24941 7/20 0.74
CCNE2 O96020 5/20 0.74
CCNE1 P24864 5/20 0.74
CCNA1 P78396 5/20 0.74
CCNB2 O95067 4/20 0.74
CDK1 P06493 4/20 0.74
CCNB1 P14635 4/20 0.74
CCNB3 Q8WWL7 4/20 0.74
CDK6 Q00534 2/20 0.71
MARK3 P27448 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6944231 0.90 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL7071397 0.89 CDK4 (0.98) CDK4CCND1CCND2CCND3FGFR1
Trifluoroacetic Acid SCHEMBL6942948 0.88 CDK4 (0.77) CDK4CCND1CCND2CCND3FGFR1
Hydrochloric Acid SCHEMBL6938660 0.87 CDK4 (0.98) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL27572260 0.86 CDK4 (0.76) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL11977134 0.84 CDK4 (0.73) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL7175584 0.84 CDK4 (0.80) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL17322466 0.84 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1
Trifluoroacetic Acid SCHEMBL6938645 0.83 CDK4 (0.86) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5520444 0.83 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1268476-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2003-01-02 EP disclosed
WO-2001070741-A1 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS WARNER-LAMBERT COMPANY (US) 2001-09-27 WO disclosed