Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Beclomethasone Dipropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | USP2 | O75604 | 6/20 | 1.00 |
| ▸ | PGR | P06401 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | CNR1 | P21554 | 2/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.80 |
| ▸ | DRD2 | P14416 | 1/20 | 0.80 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MLNR | O43193 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Beclomethasone Dipropionate SCHEMBL6055708 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL10493593 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL2404673 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL6890 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL6055713 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL13653326 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL9768491 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL10392062 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL19681908 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A | |
| Beclomethasone Dipropionate SCHEMBL5095 | 1.00 | CYP3A4 (1.00) | CYP3A4USP2NR3C1PGRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57007495-A | — | — | None | — | — | JP | disclosed |
| EP-0912185-B1 | NOVEL PHARMACEUTICAL COMPOSITIONS HAVING STEROID NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | SEARLE & CO (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-0900233-B1 | STEROID NITRITE AND NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | SEARLE & CO (US) | 2000-11-29 | — | — | EP | disclosed |
| US-5985862-A | TREATING UNDESIRED SMOOTH MUSCLE CONTRACTIONS AND INFLAMMATORY DISEASES | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0912185-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS HAVING STEROID NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1999-05-06 | — | — | EP | disclosed |
| EP-0900233-A1 | NOVEL STEROID NITRITE AND NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5837698-A | DERIVATIVES OF BETA-METHASONE, DEXAMETHASONE, BUDESONIDE AND TRIAMCINOLOLE WITH NITRATE | G. D. SEARLE & CO. (US) | 1998-11-17 | — | — | US | disclosed |
| WO-1997040836-A1 | NOVEL PHARMACEUTICAL COMPOSITIONS HAVING STEROID NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997041144-A1 | NOVEL STEROID NITRITE AND NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1997-11-06 | — | — | WO | disclosed |
| US-4414209-A | Micronized aerosol steroids | ALLEN & HANBURYS LIMITED (GB) | 1983-11-08 | — | — | US | disclosed |
| US-4364923-A | Chemical compounds | ALLEN & HANBURS LIMITED (GB) | 1982-12-21 | — | — | US | disclosed |
| JP-S577495-A | PREPARATION OF 9ALPHA-CHLORO-11BETA-HYDROXYCORTICOSTEROID | MITSUBISHI CHEM IND LTD | 1982-01-14 | — | — | JP | disclosed |
| US-4024131-A | ANTIINFLAMMATORY | PLURICHEMIE ANSTALT (FL) | 1977-05-17 | — | — | US | disclosed |