Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.81 |
| ▸ | CCND1 | P24385 | 20/20 | 0.81 |
| ▸ | CCND2 | P30279 | 20/20 | 0.81 |
| ▸ | CCND3 | P30281 | 20/20 | 0.81 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.67 |
| ▸ | MARK3 | P27448 | 1/20 | 0.67 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.67 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.67 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.67 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.67 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 1/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.67 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.66 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940626 | 0.95 | CDK4 (0.78) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6939978 | 0.87 | CDK4 (0.67) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6940613 | 0.87 | CDK4 (0.67) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6942644 | 0.86 | CDK4 (0.77) | CDK4CCND1CCND2CCND3NUAK1 | |
| Trifluoroacetic Acid SCHEMBL6942641 | 0.86 | CDK4 (0.90) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6938439 | 0.84 | CDK4 (0.79) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6936478 | 0.83 | CDK4 (0.79) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6940620 | 0.83 | CDK4 (1.00) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6941075 | 0.83 | CDK4 (0.80) | CDK4CCND1CCND2CCND3NUAK1 | |
| SCHEMBL6943433 | 0.83 | CDK4 (0.76) | CDK4CCND1CCND2CCND3NUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | claimed |
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |