Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.71 |
| ▸ | CDK4 | P11802 | 1/20 | 0.71 |
| ▸ | CCND1 | P24385 | 1/20 | 0.71 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.71 |
| ▸ | CDK2 | P24941 | 1/20 | 0.71 |
| ▸ | GSK3A | P49840 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950855 | 0.87 | CCNE2 (0.66) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7079795 | 0.84 | CCNE2 (0.62) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL30319849 | 0.84 | CCNE2 (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL5686048 | 0.84 | CCNE2 (1.00) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7061077 | 0.84 | CCNE2 (0.76) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7054131 | 0.84 | CCNE2 (0.76) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7505472 | 0.82 | CCNE2 (0.78) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL8154922 | 0.81 | GSK3B (0.81) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7529336 | 0.81 | CCNE2 (0.77) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL6947545 | 0.81 | CCNE2 (0.71) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915872-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6030994-A | ANTIPROLIFERATIVE, TUMOR AND CARCINOGENIC AGENTS; PARTICULARLY FOR TREATMENT OF SOLID TUMORS AND THOSE OF THE BREAST AND COLON | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| EP-0915872-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| US-5856517-A | ANTIPROLIFERATIVE AGENTS USEFUL IN THE TREATMENT OF CANCER. | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| WO-1998004552-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |