Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16590793 | 0.77 | GBA1 (0.50) | GBA1SLC18A3CCR3MGLLGRIN2B | |
| SCHEMBL13803960 | 0.75 | GBA1 (0.55) | GBA1CCR3 | |
| SCHEMBL13803916 | 0.75 | GBA1 (0.55) | GBA1CCR3 | |
| SCHEMBL12076803 | 0.75 | GBA1 (0.55) | GBA1CCR3 | |
| SCHEMBL4577960 | 0.75 | GBA1 (0.55) | GBA1CCR3 | |
| SCHEMBL13791895 | 0.75 | GBA1 (0.55) | GBA1CCR3 | |
| SCHEMBL27644363 | 0.70 | GBA1 (0.52) | GBA1 | |
| SCHEMBL6073404 | 0.67 | GBA1 (0.48) | GBA1SLC18A3CCR3MGLLGRIN2B | |
| SCHEMBL6944306 | 0.67 | GBA1 (0.46) | GBA1 | |
| SCHEMBL6944308 | 0.67 | GBA1 (0.46) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244450-A4 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO INC (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1244450-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | Merck & Co., Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6432976-B1 | ANALGESICS; SIDE EFFECT REDUCTION | MERCK & CO., INC. | 2002-08-13 | — | — | US | disclosed |
| WO-2001032179-A1 | 8-AZA-BICYCLO[3.2.1]OCTANE NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2001-05-10 | — | — | WO | disclosed |