Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.66 |
| ▸ | CCND1 | P24385 | 20/20 | 0.66 |
| ▸ | CCND3 | P30281 | 16/20 | 0.66 |
| ▸ | CCND2 | P30279 | 15/20 | 0.66 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.60 |
| ▸ | CDK1 | P06493 | 5/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.53 |
| ▸ | CDK2 | P24941 | 10/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945561 | 0.93 | CDK4 (0.65) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6945970 | 0.92 | CDK4 (0.67) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6942106 | 0.90 | CDK4 (0.79) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6938615 | 0.89 | CDK4 (0.82) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6944903 | 0.88 | CDK4 (0.78) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL22171205 | 0.83 | CCND1 (0.63) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6943792 | 0.83 | CDK4 (0.68) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL22165707 | 0.83 | CDK4 (0.53) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL6945279 | 0.82 | CDK4 (0.77) | CDK4CCND1CCND3CCND2CCNB2 | |
| SCHEMBL7072243 | 0.82 | CDK4 (0.57) | CDK4CCND1CCND3CCND2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268476-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070741-A1 | 5-ALKYLPYRIDO[2,3-D]PYRIMIDINES TYROSINE KINASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |