Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944335 | 0.89 | MAP2K1 (0.41) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL6948913 | 0.88 | MAP2K1 (0.43) | KMT2AMEN1MAP2K1MAPK1SMN1; SMN2 | |
| SCHEMBL6950406 | 0.88 | KMT2A (0.48) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL27577420 | 0.83 | KMT2A (0.40) | KMT2AMEN1MAP2K1MAPK1SMN1; SMN2 | |
| SCHEMBL5403672 | 0.83 | MEN1 (0.66) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL6950462 | 0.81 | MEN1 (0.76) | KMT2AMEN1TDP1MAP2K1MAP2K2 | |
| SCHEMBL6950416 | 0.80 | MEN1 (0.47) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL6949203 | 0.80 | MEN1 (0.47) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL6946179 | 0.79 | MEN1 (0.46) | KMT2AMEN1TDP1MAP2K1MAPK1 | |
| SCHEMBL6946807 | 0.79 | KMT2A (0.46) | KMT2AMEN1TDP1MAP2K1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |