SCHEMBL6944894

SCHEMBL6944894

CS(=O)(=O)OC[C@@](O)(Cn1cncn1)c1ccc(F)cc1F

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 16/20 0.74
CYP2C9 P11712 12/20 0.74
CYP2C19 P33261 12/20 0.74
LMNA P02545 2/20 0.74
HSP90AA1 P07900 1/20 0.74
CYP19A1 P11511 1/20 0.74
CYP11B1 P15538 1/20 0.74
CYP11B2 P19099 1/20 0.74
ADRA1A P35348 1/20 0.74
CYP51A1 Q16850 1/20 0.74
HDAC3 O15379 2/20 0.50
HDAC4 P56524 2/20 0.50
HDAC1 Q13547 2/20 0.50
HDAC7 Q8WUI4 2/20 0.50
HDAC2 Q92769 2/20 0.50
HDAC10 Q969S8 2/20 0.50
HDAC11 Q96DB2 2/20 0.50
HDAC8 Q9BY41 2/20 0.50
HDAC6 Q9UBN7 2/20 0.50
HDAC9 Q9UKV0 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6946735 1.00 CYP3A4 (0.74) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL18717337 0.91 CYP3A4 (0.69) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
SCHEMBL26094039 0.91 CYP3A4 (0.69) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL6937751 0.90 CYP3A4 (0.83) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL6377948 0.86 CYP3A4 (0.95) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL3151 0.86 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL5503188 0.86 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL29360276 0.86 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL5597261 0.86 CYP3A4 (1.00) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1
Fluconazole SCHEMBL6378035 0.85 CYP3A4 (0.88) CYP3A4CYP2C9CYP2C19LMNAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773941-B1 TETRAHYDROFURAN ANTIFUNGALS SCHERING CORP (US) 2003-05-14 EP disclosed
EP-0736030-B1 TETRAHYDROFURAN ANTIFUNGALS SCHERING CORP (US) 2001-08-29 EP disclosed
EP-0610377-B1 TRI-SUBSTITUTED TETRAHYDROFURAN ANTIFUNGALS SCHERING CORP (US) 2001-01-24 EP disclosed
US-5714490-A 4-(4-(4-(-((5-(2,4-DIHALOPHENYL)--TETRAHYDRO-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)TETRAHYDROFUR-3-YL)METHOXY)PHENYL)-2,4-DIHYDRO-2-(MONO- OR DIHYDROXYALKYL)-3H-1,2,4-TRIAZOL-3-ONE; BROAD SPECTRUM; WATER SOLUBILITY; ASPERGILLUS; CANDIDA SCHERING CORPORATION (US) 1998-02-03 US disclosed
US-5710154-A Tetrahydrofuran antifungals SCHERING CORPORATION (US) 1998-01-20 US disclosed
US-5703079-A Tetrahydrofuran antifungals SCHERING CORPORATION (US) 1997-12-30 US disclosed
US-5698557-A Hydroxy-substituted antifungals SCHERING CORPORATION (US) 1997-12-16 US disclosed
US-5693626-A TREATING OR PREVENTING FUNGAL INFECTIONS BY ORAL OR PARENTERAL ADMINISTRATION SCHERING CORPORATION (US) 1997-12-02 US disclosed
US-5661151-A Tetrahydrofuran antifungals SCHERING CORPORATION (US) 1997-08-26 US disclosed
WO-1997000248-A1 HYDROXYALKYL-SUBSTITUTED TRIAZOLONES ANTIFUNGALS SCHERING CORPORATION (US) 1997-01-03 WO disclosed
WO-1996038443-A1 TETRAHYDROFURAN ANTIFUNGALS SCHERING CORPORATION (US) 1996-12-05 WO disclosed
WO-1995017407-A1 TETRAHYDROFURAN ANTIFUNGALS SCHERING CORPORATION (US) 1995-06-29 WO disclosed
EP-0610377-A1 TRI-SUBSTITUTED TETRAHYDROFURAN ANTIFUNGALS SCHERING CORPORATION (US) 1994-08-17 EP disclosed
WO-1993009114-A1 TRI-SUBSTITUTED TETRAHYDROFURAN ANTIFUNGALS SCHERING CORPORATION (US) 1993-05-13 WO disclosed
EP-0539938-A1 Tri-substituted tetrahydrofuran antifungals SCHERING CORPORATION (US) 1993-05-05 EP disclosed