Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6950416 | 0.88 | MEN1 (0.47) | MAP2K1MAP2K2HDAC1HDAC6 | |
| SCHEMBL6946588 | 0.88 | MAP2K1 (0.55) | MAP2K1MAP2K2 | |
| SCHEMBL6946169 | 0.86 | MAP2K1 (0.53) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL6946674 | 0.85 | MAP2K1 (0.42) | MAP2K1MAP2K2HDAC1HDAC6 | |
| SCHEMBL5991182 | 0.83 | MAP2K1 (0.64) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL5388138 | 0.82 | MAP2K1 (0.60) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL6945033 | 0.81 | MAP2K1 (0.61) | MAP2K1MAP2K2PIM1CAMK2B | |
| SCHEMBL6948913 | 0.80 | MAP2K1 (0.43) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL6945746 | 0.79 | MAP2K1 (0.42) | MAP2K1MAP2K2HDAC3HDAC4HDAC1 | |
| SCHEMBL6944532 | 0.79 | MEN1 (0.47) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |