Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 3/20 | 0.74 |
| ▸ | PGK2 | P07205 | 3/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 15/20 | 0.67 |
| ▸ | PTPRC | P08575 | 2/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.53 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.53 |
| ▸ | PTPRB | P23467 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947737 | 0.93 | PTPN1 (0.76) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6946496 | 0.90 | PTPN1 (0.76) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6944215 | 0.86 | PTPN1 (0.67) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6943702 | 0.82 | PTPN1 (0.88) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6951072 | 0.81 | PTPN1 (0.65) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6949964 | 0.81 | PTPN1 (0.72) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6947267 | 0.81 | PTPN1 (1.00) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6944081 | 0.80 | PTPN1 (0.64) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6946525 | 0.78 | PTPN1 (0.64) | PGK1PGK2PTPN1PTPRCPTPN2 | |
| SCHEMBL6952067 | 0.74 | PTPN1 (1.00) | PGK1PGK2PTPN1PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | claimed |
| EP-1115729-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | Merck Frosst Canada & Co. (CA) | 2001-07-18 | — | — | EP | claimed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | claimed |
| WO-2000017211-A1 | PHOSPHONIC ACIDS DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA & CO. (CA) | 2000-03-30 | — | — | WO | claimed |
| EP-1115729-B1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA INC (CA) | 2003-02-19 | — | — | EP | disclosed |
| EP-1115729-A1 | PHOSPHONIC ACID DERIVATIVES AS INHIBITORS OF PTP-1B | Merck Frosst Canada & Co. (CA) | 2001-07-18 | — | — | EP | disclosed |
| US-6174874-B1 | ANTIDIABETIC,-CARCINOGENIC AGENTS; IMPROVING GLUCOSE TOLERANCE/INSULIN-SENSITIVITY; PREVENTING/TREATING OBESITY AND NEURODEGENERATIVE DISEASES; E.G. 1,3-BIS-((PHOSPHONODI-FLUOROMETHYL)PHENYL)-2-DICARBOXYPROPANE | MERCK FROSST CANADA & CO. (CA) | 2001-01-16 | — | — | US | disclosed |
| WO-2000017211-A1 | PHOSPHONIC ACIDS DERIVATIVES AS INHIBITORS OF PTP-1B | MERCK FROSST CANADA & CO. (CA) | 2000-03-30 | — | — | WO | disclosed |