SCHEMBL6947237

SCHEMBL6947237

COC(=O)[C@@H](O)[C@@H](CC(C)C)C(=O)OC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MME P08473 2/20 0.39
MMP2 P08253 5/20 0.38
MMP8 P22894 4/20 0.38
MMP9 P14780 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
TAS1R3 Q7RTX0 4/20 0.37
TAS1R1 Q7RTX1 4/20 0.37
MMP1 P03956 3/20 0.37
MMP3 P08254 2/20 0.35
MMP7 P09237 2/20 0.35
MMP20 O60882 1/20 0.35
ADAMTS4 O75173 1/20 0.35
TNF P01375 1/20 0.35
MMP10 P09238 1/20 0.35
MMP12 P39900 1/20 0.35
MMP13 P45452 1/20 0.35
MMP14 P50281 1/20 0.35
MMP15 P51511 1/20 0.35
MMP16 P51512 1/20 0.35
ADAM17 P78536 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6655326 0.88 MME (0.44) MMEMMP2MMP8MMP9TAS1R3
SCHEMBL6655329 0.88 MME (0.44) MMEMMP2MMP8MMP9TAS1R3
SCHEMBL16487289 0.86 MME (0.43) MMESMN1; SMN2TAS1R3TAS1R1BIRC2
SCHEMBL6942402 0.82 TDP1 (0.40) MMEMMP2MMP8MMP9TAS1R3
SCHEMBL6942403 0.82 TDP1 (0.40) MMEMMP2MMP8MMP9TAS1R3
SCHEMBL5514853 0.82 SMN1; SMN2 (0.44) MMESMN1; SMN2TAS1R3TAS1R1ADAM17
SCHEMBL9911582 0.82 SMN1; SMN2 (0.44) MMESMN1; SMN2TAS1R3TAS1R1ADAM17
SCHEMBL12868880 0.82 SMN1; SMN2 (0.44) MMESMN1; SMN2TAS1R3TAS1R1ADAM17
SCHEMBL15015675 0.78 MME (0.46) MMESMN1; SMN2TAS1R3TAS1R1FOLH1
SCHEMBL4891303 0.77 CA1 (0.42) MMP2MMP8SMN1; SMN2MMP1CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1030842-B1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARM (GB) 2003-04-02 EP disclosed
EP-0835240-B1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARM (GB) 2000-11-02 EP disclosed
EP-1030842-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 2000-08-30 EP disclosed
EP-0821668-B1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARM (GB) 2000-08-23 EP disclosed
US-5919940-A TERT-LEUCINE-THIAZOL-2-YLAMIDE BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-07-06 US disclosed
US-5917090-A INHIBIT TUMOR NECROSIS FACTOR; ANTIARTHRITIC AGENTS BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) 1999-06-29 US disclosed
US-5908851-A TUMOR NECROSIS FACTOR, COLLAGENASE, STROMELYSIN, AND GELATINASE INHIBITORS; OSTEOPOROSIS, RHEUMATIC AND ORAL DISEASES; ANTIARTHRITIC AND ANTIULCER AGENTS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-06-01 US disclosed
WO-1999025693-A1 METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-05-27 WO disclosed
US-5859253-A L-TERT-LEUCINE-2-PYRIDYLAMIDE BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1999-01-12 US disclosed
US-5747514-A Metalloproteinase inhibitors BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-05-05 US disclosed
EP-0835240-A1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-04-15 EP disclosed
EP-0821668-A1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1998-02-04 EP disclosed
WO-1997003966-A1 N-(AMINO ACID) SUBSTITUTED SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-02-06 WO disclosed
WO-1997002239-A1 MATRIX METALLOPROTEINASE INHIBITORS BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1997-01-23 WO disclosed
WO-1996033165-A1 DERIVATIVES OF SUCCINAMIDE AND THEIR USE AS METALLOPROTEINASE INHIBITOR BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) 1996-10-24 WO disclosed