SCHEMBL694758

SCHEMBL694758

FC(F)(F)c1ccc(-c2cc3c[c]ccc3[nH]2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 1/20 0.43
CDK1 P06493 1/20 0.43
CCNB1 P14635 1/20 0.43
GSK3A P49840 1/20 0.43
GSK3B P49841 1/20 0.43
CCNB3 Q8WWL7 1/20 0.43
HDAC11 Q96DB2 2/20 0.41
HPN P05981 1/20 0.41
MAPT P10636 3/20 0.39
ALDH1A1 P00352 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PARP1 P09874 1/20 0.39
TNKS O95271 1/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
KDM4E B2RXH2 2/20 0.38
CASP3 P42574 2/20 0.38
SENP8 Q96LD8 2/20 0.38
SENP7 Q9BQF6 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL695489 0.84 SCN2A (0.47) MAPTALDH1A1SMN1; SMN2PARP1NPC1
SCHEMBL695386 0.82 CYP1A1 (0.45) CCNB2CDK1CCNB1GSK3AGSK3B
SCHEMBL693516 0.81 KDM4E (0.42) MAPTNPC1RAB9AKDM4ECASP3
SCHEMBL30047184 0.79 NPC1 (0.65) CCNB2CDK1CCNB1GSK3AGSK3B
SCHEMBL693863 0.79 CLK1 (0.42) MAPTALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL4893046 0.79 NPC1 (0.65) CCNB2CDK1CCNB1GSK3AGSK3B
SCHEMBL699731 0.79 PIK3CA (0.38)
SCHEMBL695181 0.79 NPSR1 (0.37) KDM4ECASP3CYP1A2KIF11
SCHEMBL694898 0.78 NPC1 (0.63) MAPTALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL695754 0.76 CYP19A1 (0.56) CCNB2CDK1CCNB1GSK3AGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2421825-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP claimed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO claimed
EP-3197450-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-08-02 EP disclosed
WO-2016046130-A1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2016-03-31 WO disclosed
EP-2421825-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS Janssen Pharmaceutica N.V. (BE) 2012-02-29 EP disclosed
WO-2010124108-A1 AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2010-10-28 WO disclosed