Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 20/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | DRD2 | P14416 | 1/20 | 0.86 |
| ▸ | HTR1D | P28221 | 1/20 | 0.86 |
| ▸ | HTR2C | P28335 | 1/20 | 0.86 |
| ▸ | HTR1F | P30939 | 1/20 | 0.86 |
| ▸ | HTR2B | P41595 | 1/20 | 0.86 |
| ▸ | HTR6 | P50406 | 1/20 | 0.86 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947849 | 1.00 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6948158 | 0.95 | UTS2R (0.91) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6949869 | 0.95 | UTS2R (0.91) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6944299 | 0.93 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6944305 | 0.93 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6950596 | 0.93 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6946622 | 0.93 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6949612 | 0.89 | UTS2R (0.94) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6951728 | 0.89 | UTS2R (0.94) | UTS2RHTR1ACYP2D6DRD2HTR1D | |
| SCHEMBL6950604 | 0.88 | UTS2R (1.00) | UTS2RHTR1ACYP2D6DRD2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244452-B1 | CARBOXAMIDE DERIVATES OF PYRROLIDINE AND PIPERIDINE AS UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | claimed |
| US-6544992-B1 | Carbonylamino pyrrolidine and piperidine derivatives | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | claimed |
| EP-1244452-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1244452-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2001045711-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | claimed |
| EP-1244452-B1 | CARBOXAMIDE DERIVATES OF PYRROLIDINE AND PIPERIDINE AS UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6544992-B1 | Carbonylamino pyrrolidine and piperidine derivatives | SMITHKLINE BEECHAM CORPORATION | 2003-04-08 | — | — | US | disclosed |
| EP-1244452-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1244452-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001045711-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-06-28 | — | — | WO | disclosed |