Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TOP1 | P11387 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007031 | 1.00 | KCNH2 (0.56) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6951491 | 1.00 | KCNH2 (0.56) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2181574 | 0.93 | KCNH2 (0.56) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2182802 | 0.93 | KCNH2 (0.56) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5546134 | 0.93 | KCNH2 (0.56) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2181304 | 0.93 | KCNH2 (0.55) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5544793 | 0.93 | KCNH2 (0.55) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6956945 | 0.90 | KCNH2 (0.69) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6947574 | 0.90 | KCNH2 (0.69) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6947572 | 0.90 | KCNH2 (0.69) | KCNH2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656952-B2 | As antibiotics | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-12-02 | — | — | US | claimed |
| EP-0995744-B1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-02-12 | — | — | EP | claimed |
| US-20020072608-A1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-13 | — | — | US | claimed |
| EP-0995744-A1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-26 | — | — | EP | claimed |
| US-6656952-B2 | As antibiotics | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-12-02 | — | — | US | disclosed |
| EP-0995744-B1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-02-12 | — | — | EP | disclosed |
| US-20020072608-A1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVE | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2002-06-13 | — | — | US | disclosed |
| EP-0995744-A1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072608-A1 | CIS-SUBSTITUTED FLUOROMETHYLPYRROLIDINE DERIVATIVE | Q6ZSR9, MRPL21, ABCC1 | KCNH2 130/4885KDM4E 707/4885ALDH1A1 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.