Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948664 | 1.00 | KCNH2 (0.54) | KCNH2HTR2AHRH2HRH1KDM4E | |
| SCHEMBL6947200 | 0.94 | HTR2A (0.57) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL6947854 | 0.94 | HTR2A (0.57) | KCNH2HTR2AKDM4ECYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8867634 | 0.93 | HTR2A (0.56) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8867625 | 0.93 | HTR2A (0.56) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6952317 | 0.92 | HRH2 (0.49) | KCNH2HTR2AHRH2HRH1HRH3 | |
| SCHEMBL6952321 | 0.92 | HRH2 (0.49) | KCNH2HTR2AHRH2HRH1HRH3 | |
| SCHEMBL6947026 | 0.92 | MEN1 (0.53) | KCNH2HTR2AHRH2HRH1KDM4E | |
| SCHEMBL6947024 | 0.92 | MEN1 (0.53) | KCNH2HTR2AHRH2HRH1KDM4E | |
| SCHEMBL6953050 | 0.91 | HTR2A (0.53) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709378-B1 | Aminoalkyloximes, a process for their preparation, their use as medicaments and intermediate compounds | AVENTIS PHARMA INC (US) | 2003-03-19 | — | — | EP | disclosed |
| US-5665756-A | Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders | HOECHST MARION ROUSSEL, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5648367-A | ANTIDEPRESANTS, OBSESSIVE-COMPULSIVE DISORDER | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0709378-A2 | Aminoalkyloximes, a process for their preparation, their use as medicaments and intermediate compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1996-05-01 | — | — | EP | disclosed |