Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.65 |
| ▸ | MAP2K2 | P36507 | 14/20 | 0.53 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.42 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947283 | 0.87 | MAP2K1 (0.54) | MAP2K1MAP2K2CLCN2 | |
| SCHEMBL22428819 | 0.82 | MAP2K1 (0.73) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6944092 | 0.80 | MAP2K1 (0.67) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6944061 | 0.80 | MAP2K1 (0.73) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL1488147 | 0.79 | MAP2K1 (0.73) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL29413453 | 0.79 | MAP2K1 (0.73) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| Zapnometinib SCHEMBL30298104 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| Zapnometinib SCHEMBL29362260 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| Zapnometinib SCHEMBL1488782 | 0.79 | MAP2K1 (1.00) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL6948257 | 0.76 | MAP2K1 (0.68) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | claimed |
| JP-2003504401-A | — | — | 2003-02-04 | — | — | JP | claimed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | claimed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | claimed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | claimed |
| EP-1202724-B1 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER LAMBERT CO (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-1202724-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| EP-1150950-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2001005393-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000041505-A2 | ANTHRANILIC ACID DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |