Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 4/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956140 | 1.00 | EPHX2 (0.50) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL5385396 | 0.91 | CA12 (0.45) | EPHX2SIGMAR1KDM5APHF8KDM4C | |
| SCHEMBL28376891 | 0.84 | EPHX2 (0.55) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL7349895 | 0.83 | EPHX2 (0.50) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL2182224 | 0.83 | EPHX2 (0.53) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL4885883 | 0.83 | EPHX2 (0.62) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL8861106 | 0.83 | EPHX2 (0.53) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL28238363 | 0.83 | EPHX2 (0.53) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL17817233 | 0.83 | EPHX2 (0.53) | EPHX2DNM1SIGMAR1KDM5APHF8 | |
| SCHEMBL18760168 | 0.83 | EPHX2 (0.53) | EPHX2DNM1SIGMAR1KDM5APHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105377-B1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2003-10-08 | — | — | EP | disclosed |
| US-6559155-B1 | Phospholipase A2 enzyme Lipoprotein Associated Phospholipase A2 inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-05-06 | — | — | US | disclosed |
| EP-1105377-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-13 | — | — | EP | disclosed |
| WO-2000010980-A1 | PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2000-03-02 | — | — | WO | disclosed |