Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 8/20 | 0.66 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | PRKCG | P05129 | 1/20 | 0.66 |
| ▸ | PRKCB | P05771 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | PRKCA | P17252 | 1/20 | 0.66 |
| ▸ | PRKCH | P24723 | 1/20 | 0.66 |
| ▸ | PRKCI | P41743 | 1/20 | 0.66 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.66 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.66 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.66 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.66 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.59 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.59 |
| ▸ | IKBKB | O14920 | 9/20 | 0.52 |
| ▸ | CHUK | O15111 | 9/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Aminophenol SCHEMBL8306819 | 0.95 | ZAP70 (0.61) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6955286 | 0.89 | ZAP70 (0.66) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6951420 | 0.89 | ZAP70 (0.66) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6952360 | 0.89 | ZAP70 (0.68) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6952805 | 0.87 | ZAP70 (0.64) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL7267007 | 0.86 | ZAP70 (0.66) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6950535 | 0.86 | ZAP70 (0.74) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6957436 | 0.86 | ZAP70 (0.66) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| Dimethylamine SCHEMBL7267011 | 0.86 | ZAP70 (0.68) | ZAP70PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL6956894 | 0.85 | ZAP70 (0.64) | ZAP70PRKD3EGFRPRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552029-B1 | For therapy of rheumatoid arthritis, psoriasis, graft v. host disease, asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, complications following percutaneous transluminal coronary angioplasty, thrombosis | CELLTECH R&D LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |
| EP-0934304-B1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-6114333-A | 2-Pyrimidineamine derivatives and processes for their preparation | CELLTECH THERAPEUTICS LTD. (GB) | 2000-09-05 | — | — | US | disclosed |