Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157824 | 0.87 | PDE4A (0.52) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1157687 | 0.87 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1158532 | 0.84 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL4193023 | 0.83 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL4199907 | 0.82 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1157704 | 0.82 | PDE4A (0.61) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1157497 | 0.81 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1157251 | 0.81 | PDE4A (0.60) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL3202108 | 0.81 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE4CGRM2 | |
| SCHEMBL1158956 | 0.81 | PDE4A (0.54) | PDE4APDE4DPDE4BPDE4CGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353907-A2 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2003-10-22 | — | — | EP | claimed |
| WO-2002074726-A2 | ANILINE DERIVATIVES USEFUL AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2002-09-26 | — | — | WO | claimed |