Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MGMT | P16455 | 4/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957503 | 0.87 | MGMT (0.44) | RAB9AMAPTPOLBMGMTBLM | |
| SCHEMBL4417411 | 0.83 | MAPT (0.48) | MAPTPOLBMGMTBLMMEN1 | |
| SCHEMBL6434735 | 0.81 | MGMT (0.37) | MAPTMGMTBLMMEN1KMT2A | |
| SCHEMBL6953559 | 0.78 | MAPT (0.49) | MAPTPOLBMGMTBLMMEN1 | |
| SCHEMBL6947678 | 0.78 | MGMT (0.42) | RAB9AMAPTPOLBMGMTMEN1 | |
| SCHEMBL6950705 | 0.77 | MAPT (0.40) | RAB9AMAPTPOLBMEN1KMT2A | |
| SCHEMBL6951003 | 0.76 | MGMT (0.42) | RAB9AMAPTPOLBMGMTMEN1 | |
| SCHEMBL6945292 | 0.76 | MGMT (0.45) | RAB9AMAPTPOLBMGMTMEN1 | |
| SCHEMBL6950817 | 0.76 | TYMS (0.44) | RAB9AMAPTPOLBMEN1KMT2A | |
| SCHEMBL6950115 | 0.76 | MGMT (0.37) | RAB9AMGMTGPR119HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074549-B1 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | HOFFMANN LA ROCHE (CH) | 2003-11-19 | — | — | EP | disclosed |
| US-6218385-B1 | FOR THERAPY OR PROPHYLAXIS OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS SUCH AS EPILEPSY, STROKE, CHRONIC AND ACUTE PAIN, PSYCHOSIS, SCHIZOPHRENIA, ALZHEIMER'S DISEASE, COGNITIVE DISORDERS AND MEMORY DEFICITS | HOFFMANN-LA ROCHE INC. | 2001-04-17 | — | — | US | disclosed |
| EP-1074549-A2 | Tetrahydro-benzo(d)azepines and their use as antagonists at metabotropic glutamate receptors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-07 | — | — | EP | disclosed |