Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954090 | 1.00 | MAPT (0.51) | MAPTNPSR1POLBLY96HPGD | |
| SCHEMBL7384129 | 0.82 | MAPT (0.53) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL7384130 | 0.82 | MAPT (0.53) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL7378695 | 0.81 | CYP1A2 (0.63) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL10353470 | 0.81 | MAPT (0.61) | MAPTNPSR1POLBCYP3A4CYP2C9 | |
| SCHEMBL3194980 | 0.81 | MAPT (0.55) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL7378697 | 0.81 | CYP1A2 (0.63) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL3183430 | 0.81 | MAPT (0.55) | MAPTNPSR1POLBCYP1A2CYP3A4 | |
| SCHEMBL11002399 | 0.81 | MAPT (0.61) | MAPTNPSR1POLBCYP3A4CYP2C9 | |
| SCHEMBL7978583 | 0.79 | MAPT (0.42) | MAPTNPSR1HPGDCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023267-B1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL SA (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6482841-B1 | Pyridyl compounds and pharmaceutical compositions containing them | CERMOL S.A. (CH) | 2002-11-19 | — | — | US | disclosed |
| EP-1023267-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999019302-A1 | PYRIDYL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CERMOL S.A. (CH) | 1999-04-22 | — | — | WO | disclosed |