Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 8/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12948683 | 0.84 | MAOB (0.64) | MIFMAOBMAPTPKMNFKB1 | |
| SCHEMBL980276 | 0.84 | MAOB (0.64) | MIFMAOBMAPTPKMNFKB1 | |
| SCHEMBL30832112 | 0.81 | MAPT (0.83) | MIFMAOBMAPTPKMNFKB1 | |
| SCHEMBL12948685 | 0.79 | MAPT (0.84) | MIFMAOBMAPTPKMNFKB1 | |
| SCHEMBL28095979 | 0.78 | MAPT (0.65) | MIFMAOBMAPTPKMSMN1; SMN2 | |
| SCHEMBL11821606 | 0.78 | DYRK2 (0.69) | MAPTNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL11845990 | 0.78 | DYRK2 (0.69) | MAPTNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL11821611 | 0.78 | DYRK2 (0.69) | MAPTNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL11845989 | 0.78 | DYRK2 (0.69) | MAPTNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL8543003 | 0.78 | MAOB (1.00) | MIFMAOBMAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023063-B1 | INDENO[1,2-c], NAPHTHO[1,2-c]- AND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLE DERIVATIVES | ABBOTT GMBH & CO KG (DE) | 2003-09-10 | — | — | EP | disclosed |