Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955138 | 1.00 | KDM4E (0.49) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL6955143 | 1.00 | KDM4E (0.49) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL27533293 | 0.87 | SMN1; SMN2 (0.50) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL7668857 | 0.84 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL7668864 | 0.84 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL7668869 | 0.84 | KDM4E (0.47) | KDM4EHPGDSMN1; SMN2F2PLG | |
| SCHEMBL6963090 | 0.84 | CYP2A6 (0.49) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL6963096 | 0.84 | CYP2A6 (0.49) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL6963084 | 0.84 | CYP2A6 (0.49) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL9953165 | 0.81 | CYP1A2 (0.47) | KDM4EHPGDSMN1; SMN2F2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |