Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | PRKCG | P05129 | 2/20 | 0.52 |
| ▸ | PRKCB | P05771 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | PRKCA | P17252 | 2/20 | 0.52 |
| ▸ | PRKCH | P24723 | 2/20 | 0.52 |
| ▸ | PRKCI | P41743 | 2/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6952024 | 0.86 | EGFR (0.77) | PIK3CGPIK3CAPIK3CBZAP70CDK2 | |
| SCHEMBL8151919 | 0.84 | PIK3CG (0.55) | PIK3CGPIK3CAPIK3CBZAP70CDK2 | |
| SCHEMBL6957358 | 0.83 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CBZAP70CDK2 | |
| SCHEMBL17153052 | 0.81 | ABL1 (0.53) | PIK3CGPIK3CAPIK3CBZAP70SRC | |
| SCHEMBL12921620 | 0.78 | PIK3CA (0.51) | PIK3CGPIK3CAPIK3CBZAP70SRC | |
| SCHEMBL3510842 | 0.78 | ABL1 (0.75) | PIK3CGPIK3CAPIK3CBSRCCDK2 | |
| SCHEMBL17153042 | 0.78 | ABL1 (0.60) | PIK3CGPIK3CAPIK3CBZAP70SRC | |
| SCHEMBL6950873 | 0.77 | ZAP70 (0.79) | PIK3CGPIK3CAPIK3CBZAP70SRC | |
| SCHEMBL12801643 | 0.76 | CDK5 (0.82) | PIK3CGPIK3CAPIK3CBZAP70SRC | |
| SCHEMBL4732715 | 0.76 | PIK3CG (0.61) | PIK3CGPIK3CAPIK3CBZAP70SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552029-B1 | For therapy of rheumatoid arthritis, psoriasis, graft v. host disease, asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, complications following percutaneous transluminal coronary angioplasty, thrombosis | CELLTECH R&D LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |
| EP-0934304-B1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LTD (GB) | 2003-02-26 | — | — | EP | disclosed |
| US-6114333-A | 2-Pyrimidineamine derivatives and processes for their preparation | CELLTECH THERAPEUTICS LTD. (GB) | 2000-09-05 | — | — | US | disclosed |
| EP-0934304-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998018782-A1 | 2-PYRIMIDINEAMINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-05-07 | — | — | WO | disclosed |