Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.70 |
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | BACE1 | P56817 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10061923 | 0.88 | NR1H4 (0.71) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL13755053 | 0.87 | NR1H4 (0.62) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL7031467 | 0.86 | NR1H4 (0.90) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL7031464 | 0.85 | NR1H4 (0.76) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL3662420 | 0.84 | NR1H4 (0.63) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL3915887 | 0.84 | NR1H4 (0.59) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL3662418 | 0.84 | NR1H4 (0.63) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL3915891 | 0.84 | NR1H4 (0.59) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL8913229 | 0.83 | MEN1 (0.62) | NR1H4GSK3BBACE1KDM4ENPC1 | |
| SCHEMBL5607008 | 0.83 | NR1H4 (0.61) | NR1H4GSK3BBACE1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |