Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968576 | 0.91 | TACR1 (0.45) | TACR1TACR2 | |
| SCHEMBL6962400 | 0.81 | TACR1 (0.47) | TACR1TACR2 | |
| SCHEMBL6956287 | 0.80 | TACR1 (0.45) | TACR1TACR2 | |
| SCHEMBL8861327 | 0.76 | TACR1 (0.77) | TACR1TACR2 | |
| SCHEMBL6956698 | 0.73 | TACR1 (0.40) | TACR1TACR2 | |
| SCHEMBL5086634 | 0.70 | SLC6A4 (0.64) | — | |
| SCHEMBL7139722 | 0.69 | TACR2 (0.52) | TACR1TACR2 | |
| SCHEMBL7139720 | 0.69 | TACR2 (0.52) | TACR1TACR2 | |
| SCHEMBL7371366 | 0.69 | SLC6A4 (0.63) | — | |
| SCHEMBL6962536 | 0.68 | TACR1 (0.48) | TACR1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790248-B1 | 3-Aza-piperidone- (tetrahydropyrimidin-2-one) and 3-oxa-piperidone (1,3 oxazin-2-one) derivatives, their preparation and their use as tachykinin/neurokinin antagonists | PFIZER LTD (GB) | 2003-05-28 | — | — | EP | disclosed |
| US-5846965-A | 3-aza and 3-oxa piperidone tachykinin antagonists | PFIZER INC. (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0790248-A1 | 3-Aza-piperidone- (tetrahydropyrimidin-2-one) and 3-oxa-piperidone (1,3 oxazin-2-one) derivatives, their preparation and their use as tachykinin/neurokinin antagonists | Pfizer Limited (GB) | 1997-08-20 | — | — | EP | disclosed |