Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134948 | 0.87 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL7134955 | 0.87 | SLC6A4 (0.66) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A2 | |
| SCHEMBL3466983 | 0.83 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL1981733 | 0.83 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3466313 | 0.83 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3466065 | 0.83 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL1981732 | 0.83 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL13345113 | 0.83 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3466068 | 0.83 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL13345104 | 0.82 | SLC6A4 (0.71) | SLC6A4SLC6A3SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |