Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 16/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958421 | 1.00 | FDFT1 (0.48) | FDFT1HTTNPSR1 | |
| SCHEMBL6958432 | 1.00 | FDFT1 (0.48) | FDFT1HTTNPSR1 | |
| SCHEMBL6955037 | 0.92 | FDFT1 (0.48) | FDFT1 | |
| SCHEMBL6955035 | 0.92 | FDFT1 (0.48) | FDFT1 | |
| SCHEMBL6955033 | 0.92 | FDFT1 (0.48) | FDFT1 | |
| Acetic Acid SCHEMBL6956851 | 0.90 | FDFT1 (0.52) | FDFT1 | |
| SCHEMBL6962009 | 0.89 | FDFT1 (0.51) | FDFT1 | |
| SCHEMBL6962016 | 0.89 | FDFT1 (0.51) | FDFT1 | |
| SCHEMBL6963107 | 0.86 | FDFT1 (0.54) | FDFT1 | |
| SCHEMBL6963109 | 0.86 | FDFT1 (0.54) | FDFT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567026-B1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5885979-A | SQUALENE SYNTHETASE INHIBITOR TREATING OR PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5726306-A | INHIBITORS OF SQUALENE SYNTHETASE AND FUNGAL GROWTH; USEFUL IN TREATING AND PREVENTING HYPERLIPIDEMIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-10 | — | — | US | disclosed |
| EP-0567026-A1 | 4,1-Benzoxazepin derivatives as squalene synthase inhibitors and their use in the treatment of hypercholesteremia and as fungicides | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-27 | — | — | EP | disclosed |