Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6956098 | 1.00 | MEN1 (0.39) | MEN1KMT2AHTTPDE4BKDM1A | |
| SCHEMBL6949915 | 0.93 | KMT2A (0.41) | MEN1KMT2AHTT | |
| SCHEMBL7074937 | 0.91 | MEN1 (0.41) | MEN1KMT2AHTTPDE4BKDM1A | |
| SCHEMBL6951315 | 0.90 | PDE4B (0.41) | MEN1KMT2AHTTPDE4B | |
| SCHEMBL6954512 | 0.90 | PDE4B (0.43) | MEN1KMT2AHTTPDE4BKDM1A | |
| SCHEMBL6959516 | 0.89 | KMT2A (0.39) | MEN1KMT2AHTTPDE4BKDM1A | |
| SCHEMBL6959509 | 0.88 | NPC1 (0.44) | KDM1AMAOAMAOBYAP1 | |
| SCHEMBL6956320 | 0.88 | MEN1 (0.40) | MEN1KMT2AKDM1A | |
| SCHEMBL6954704 | 0.87 | MEN1 (0.41) | MEN1KMT2AHTTKDM1AMAOA | |
| SCHEMBL6956951 | 0.86 | PPARA (0.40) | MEN1KMT2AHTTPDE4BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |