Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309013 | 0.95 | SIRT2 (0.47) | SIRT2HRH1CYP11B1CYP11B2KIF11 | |
| SCHEMBL2035093 | 0.89 | SIRT2 (0.49) | SIRT2HRH1CYP11B1CYP11B2CYP2C9 | |
| SCHEMBL8165853 | 0.87 | SIRT2 (0.47) | SIRT2HRH1MAOACYP11B1CYP11B2 | |
| SCHEMBL4682888 | 0.85 | SIRT2 (0.46) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2490264 | 0.85 | SIRT2 (0.48) | SIRT2HRH1MAOACYP11B1CYP11B2 | |
| SCHEMBL7705343 | 0.84 | SIRT2 (0.46) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2032778 | 0.84 | SIRT2 (0.47) | SIRT2CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2796109 | 0.84 | SIRT2 (0.52) | SIRT2CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL7988290 | 0.84 | SIRT2 (0.47) | SIRT2HRH1MAOACYP11B1CYP11B2 | |
| SCHEMBL8448421 | 0.83 | SIRT2 (0.43) | SIRT2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318993-B1 | SUBSTITUTED IMIDAZOLES AS DUAL HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS | SCHERING CORP (US) | 2008-08-20 | — | — | EP | disclosed |
| CN-1461304-A | Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists | SCHERING CORP (US) | 2003-12-10 | — | — | CN | disclosed |
| EP-0882023-B1 | HISTAMINE H 3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2003-06-04 | — | — | EP | disclosed |
| US-6080871-A | ANTIHISTAMINES | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |