Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1385992 | 0.80 | NAMPT (0.44) | NAMPT | |
| SCHEMBL27487465 | 0.80 | NAMPT (0.43) | NAMPTALDH1A1 | |
| SCHEMBL5025530 | 0.79 | NAMPT (0.42) | NAMPTALDH1A1 | |
| SCHEMBL5015503 | 0.79 | CYP2A6 (0.44) | NAMPTALDH1A1 | |
| SCHEMBL5017381 | 0.79 | NAMPT (0.42) | NAMPTALDH1A1 | |
| SCHEMBL27535692 | 0.77 | CYP2A6 (0.44) | NAMPTALDH1A1 | |
| SCHEMBL8086804 | 0.77 | CYP2E1 (0.58) | KMT2AMAPK1HTTNAMPTGAA | |
| SCHEMBL4260988 | 0.76 | CYP2A6 (0.43) | NAMPTALDH1A1 | |
| SCHEMBL5016843 | 0.76 | AR (0.45) | KMT2ANAMPTALDH1A1 | |
| SCHEMBL5017240 | 0.76 | CYP2A6 (0.43) | ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664398-B2 | Reacting a derivative of erythromycin containing imidazole-1-ylcaroxylate with a pyrazolealkylamine derivative, to form a desired antibiotic | AVENTIS PHARMA S.A. (FR) | 2003-12-16 | — | — | US | disclosed |
| EP-1004592-B1 | Derivatives of erythromycin, their process of preparation and their application as medicaments | AVENTIS PHARMA SA (FR) | 2003-07-16 | — | — | EP | disclosed |
| US-6440941-B1 | REACTION WITH AMINOALKYL-SUBSTITUTED 1H-PYRAZOLE | AVENTIS PHARMA S.A. (FR) | 2002-08-27 | — | — | US | disclosed |
| EP-1004592-A1 | Derivatives of erythromycin, their process of preparation and their application as medicaments | HOECHST MARION ROUSSEL (FR) | 2000-05-31 | — | — | EP | disclosed |