SCHEMBL6959464

SCHEMBL6959464

CC(C)Oc1ccc(CCC2NC(=O)SC2=O)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.43
GLA P06280 1/20 0.41
ACACB O00763 2/20 0.40
KDM4E B2RXH2 2/20 0.39
MAPT P10636 2/20 0.38
KDM4A O75164 1/20 0.38
KDM4C Q9H3R0 1/20 0.38
MAPK1 P28482 1/20 0.38
LMNA P02545 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GAA P10253 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
P2RX3 P56373 1/20 0.36
ALDH1A1 P00352 2/20 0.36
HPGD P15428 1/20 0.36
ALOX12 P18054 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
FFAR4 Q5NUL3 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6964722 0.92 POLB (0.41) POLBGLAACACBKDM4EMAPT
SCHEMBL6960177 0.91 POLB (0.40) POLBGLAACACBKDM4EMAPT
SCHEMBL6971459 0.90 POLB (0.40) POLBGLAACACBKDM4EMAPT
SCHEMBL6959460 0.73 GLA (0.47) POLBGLAKDM4EMAPTKDM4A
SCHEMBL9803894 0.69 GLA (0.34) GLA
SCHEMBL6964713 0.68 GLA (0.45) POLBGLAKDM4EMAPTALDH1A1
SCHEMBL7160667 0.68 GLA (0.40) POLBGLAACACBKDM4EMAPT
SCHEMBL9803939 0.68 PPARG (0.36) GLAALDH1A1HPGD
SCHEMBL8887977 0.68 ESR1 (0.40) KDM4ELMNAGAAALDH1A1
SCHEMBL7166844 0.68 GLA (0.39) POLBGLAACACBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0783496-B9 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-03 EP disclosed
EP-0783496-B1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-26 EP disclosed
US-5965589-A AN ACTIVE MATERIAL HAVING HYPOGLYCEMIC ACTIVITY AND BLOOD LIPID LOWERING ACTIVITY, FOR USE AS AN ANTIDIABETIC AGENT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-12 US disclosed
EP-0783496-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-16 EP disclosed
WO-1996005186-A1 THIAZOLIDINEDIONE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-22 WO disclosed