Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | MDM2 | Q00987 | 12/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915352 | 0.81 | CYP2D6 (0.80) | CYP2D6ALDH1A1MDM2CYP3A4KDM4E | |
| SCHEMBL4915357 | 0.81 | CYP2D6 (0.80) | CYP2D6ALDH1A1MDM2CYP3A4KDM4E | |
| SCHEMBL4907039 | 0.80 | MDM2 (0.80) | CYP2D6ALDH1A1MDM2CYP3A4RAF1 | |
| SCHEMBL4907041 | 0.80 | MDM2 (0.80) | CYP2D6ALDH1A1MDM2CYP3A4RAF1 | |
| SCHEMBL6954914 | 0.79 | MDM2 (0.72) | CYP2D6ALDH1A1MDM2CYP3A4RAF1 | |
| SCHEMBL1834743 | 0.75 | MDM2 (0.76) | CYP2D6MDM2CYP3A4RAF1BRAF | |
| SCHEMBL4913469 | 0.75 | MDM2 (0.76) | CYP2D6MDM2CYP3A4RAF1BRAF | |
| SCHEMBL18569303 | 0.75 | MDM2 (0.61) | CYP2D6ALDH1A1MDM2CYP3A4RAF1 | |
| SCHEMBL4916112 | 0.75 | MDM2 (1.00) | CYP2D6ALDH1A1MDM2CYP3A4RAF1 | |
| SCHEMBL4912136 | 0.74 | MDM2 (0.84) | CYP2D6ALDH1A1MDM2RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064262-B1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| US-6344468-B1 | CARDIOVASCULAR DISEASES SUCH AS HYPERTENSION, ANGINA PECTORIS, CARDIAC INSUFFICIENCY, THROMBOSES OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-02-05 | — | — | US | disclosed |
| EP-1064262-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999042444-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-08-26 | — | — | WO | disclosed |