Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.63 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.59 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959816 | 1.00 | APP (0.63) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL6969442 | 0.87 | CYSLTR1 (0.80) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL6969444 | 0.87 | CYSLTR1 (0.80) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL6965270 | 0.84 | CYSLTR2 (0.80) | CYSLTR1CYSLTR2 | |
| SCHEMBL8190517 | 0.84 | CYSLTR2 (0.80) | CYSLTR1CYSLTR2 | |
| SCHEMBL14692550 | 0.81 | APP (0.67) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL14692549 | 0.81 | APP (0.67) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL30383239 | 0.80 | APP (0.76) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL10768190 | 0.80 | APP (0.76) | APPCYSLTR1CYSLTR2ABCG2MAOB | |
| SCHEMBL10768193 | 0.80 | APP (0.76) | APPCYSLTR1CYSLTR2ABCG2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902007-B1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2003-11-05 | — | — | EP | disclosed |
| EP-0902007-A1 | CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO. LTD. (JP) | 1999-03-17 | — | — | EP | disclosed |