⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867356 | 0.78 | — | — | |
| SCHEMBL19432257 | 0.72 | CHRNA7 (0.31) | — | |
| SCHEMBL15015640 | 0.72 | — | — | |
| SCHEMBL20514711 | 0.69 | MEN1 (0.32) | — | |
| SCHEMBL11126139 | 0.69 | MEN1 (0.32) | — | |
| SCHEMBL6969715 | 0.69 | — | — | |
| SCHEMBL588402 | 0.67 | — | — | |
| SCHEMBL556411 | 0.67 | — | — | |
| SCHEMBL6666537 | 0.67 | — | — | |
| SCHEMBL7041615 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168409-A1 | VMAT2 INHIBITORS AND METHODS OF USE | Neurocrine Biosciences, Inc. (US) | 2023-04-26 | — | — | EP | claimed |
| US-4542207-A | Heterocyclic monoazo dyes for polyester fibers | RESEARCH ASSOCIATION OF SYNTHETIC DYESTUFFS (JP) | 1985-09-17 | — | — | US | claimed |
| US-20240010647-A1 | SUBSTITUTED PYRIDO[2,1-a]ISOQUINOLINES AS VMAT2 INHIBITORS | NEUROCRINE BIOSCIENCES, INC. | 2024-01-11 | — | — | US | disclosed |
| US-11718618-B2 | Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors | NEUROCRINE BIOSCIENCES, INC. (US) | 2023-08-08 | — | — | US | disclosed |
| US-20230159528-A1 | VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. | 2023-05-25 | — | — | US | disclosed |
| EP-4168409-A1 | VMAT2 INHIBITORS AND METHODS OF USE | Neurocrine Biosciences, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| EP-3303305-B9 | 2-(PHENYLOXY OR PHENYLTHIO)PYRIMIDINE DERIVATIVES AS HERBICIDES | FMC CORP (US) | 2022-07-13 | — | — | EP | disclosed |
| EP-3943486-A1 | 2-(PHENYLOXY OR PHENYLTHIO)PYRIMIDINE DERIVATIVES AS HERBICIDES | FMC Corporation (US) | 2022-01-26 | — | — | EP | disclosed |
| EP-3303305-B1 | 2-(PHENYLOXY OR PHENYLTHIO)PYRIMIDINE DERIVATIVES AS HERBICIDES | FMC CORP (US) | 2022-01-05 | — | — | EP | disclosed |
| US-20210300879-A1 | PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES | FMC CORP (US) | 2021-09-30 | — | — | US | disclosed |
| US-11053204-B2 | Pyrimidinyloxy benzene derivatives as herbicides | FMC CORPORATION (US) | 2021-07-06 | — | — | US | disclosed |
| US-4841036-A | COLORFAST, HEAT RESISTANCE | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1989-06-20 | — | — | US | disclosed |
| US-4837309-A | IMPROVED COLORFASTNESS AND LIGHTFASTNESS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1989-06-06 | — | — | US | disclosed |
| US-4707546-A | Reactive monoazo dyestuffs | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1987-11-17 | — | — | US | disclosed |
| EP-0108570-B1 | DISAZO DYESTUFFS FOR CELLULOSE-CONTAINING FIBRES AND PROCESS FOR PREPARING THE DYESTUFF | MITSUBISHI KASEI CORPORATION (JP) | 1986-10-29 | — | — | EP | disclosed |
| EP-0131314-B1 | REACTIVE MONOAZO DYESTUFFS | MITSUBISHI KASEI CORPORATION (JP) | 1986-10-29 | — | — | EP | disclosed |
| EP-0121825-B1 | MONOAZO DYESTUFFS FOR CELLULOSE-CONTAINING FIBERS | MITSUBISHI KASEI CORPORATION (JP) | 1986-09-10 | — | — | EP | disclosed |
| US-4542207-A | Heterocyclic monoazo dyes for polyester fibers | RESEARCH ASSOCIATION OF SYNTHETIC DYESTUFFS (JP) | 1985-09-17 | — | — | US | disclosed |
| EP-0131314-A1 | Reactive monoazo dyestuffs | MITSUBISHI KASEI CORPORATION (JP) | 1985-01-16 | — | — | EP | disclosed |
| US-4313731-A | Mono-azo compound, mono-azo dye and dyeing process for polyester fibers | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1982-02-02 | — | — | US | disclosed |