Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968227 | 0.93 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL6957248 | 0.93 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL6970046 | 0.91 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL31656331 | 0.91 | EDNRA (0.73) | EDNRAEDNRB | |
| SCHEMBL6967572 | 0.91 | EDNRB (0.62) | EDNRAEDNRB | |
| SCHEMBL6960422 | 0.90 | EDNRA (0.58) | EDNRAEDNRB | |
| Clazosentan SCHEMBL1983603 | 0.89 | EDNRA (0.79) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29379450 | 0.89 | EDNRA (0.79) | EDNRAEDNRB | |
| Clazosentan SCHEMBL29581324 | 0.89 | EDNRA (0.79) | EDNRAEDNRB | |
| Clazosentan SCHEMBL6974621 | 0.88 | EDNRA (0.78) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | claimed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | claimed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | claimed |
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |