Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL696076 | 0.90 | MAP2K1 (0.57) | MAP2K1PDE3BPDE3A | |
| SCHEMBL695266 | 0.86 | MAP2K1 (0.58) | MAP2K1 | |
| SCHEMBL696871 | 0.85 | MAP2K1 (0.54) | MAP2K1 | |
| SCHEMBL696211 | 0.83 | MAP2K1 (0.56) | MAP2K1 | |
| SCHEMBL698420 | 0.83 | MAP2K1 (0.64) | MAP2K1 | |
| SCHEMBL699795 | 0.82 | MAP2K1 (0.81) | MAP2K1 | |
| SCHEMBL694614 | 0.82 | MAP2K1 (0.68) | MAP2K1 | |
| Water SCHEMBL2043985 | 0.82 | MAP2K1 (0.80) | MAP2K1 | |
| SCHEMBL696164 | 0.81 | MAP2K1 (0.60) | MAP2K1 | |
| SCHEMBL695521 | 0.81 | MAP2K1 (0.59) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421612-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | Novartis AG (CH) | 2012-02-29 | — | — | EP | claimed |
| EP-2421612-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | Novartis AG (CH) | 2012-02-29 | — | — | EP | disclosed |