Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 12/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957780 | 1.00 | GRM2 (0.57) | GRM2SIGMAR1FADS1 | |
| SCHEMBL6967219 | 1.00 | GRM2 (0.57) | GRM2SIGMAR1FADS1 | |
| SCHEMBL12728925 | 0.88 | GRM2 (0.60) | GRM2SIGMAR1 | |
| SCHEMBL7300334 | 0.88 | GRM2 (0.61) | GRM2SIGMAR1FADS1 | |
| SCHEMBL7116724 | 0.87 | GRM2 (0.45) | GRM2 | |
| SCHEMBL7116727 | 0.87 | GRM2 (0.45) | GRM2 | |
| SCHEMBL7292670 | 0.87 | GRM2 (0.59) | GRM2SIGMAR1 | |
| SCHEMBL8695799 | 0.87 | GRM2 (0.59) | GRM2SIGMAR1 | |
| SCHEMBL13298874 | 0.87 | GRM2 (0.49) | GRM2 | |
| SCHEMBL8798953 | 0.87 | GRM2 (0.57) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |
| EP-0635505-B1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GMBH (DE) | 1997-10-15 | — | — | EP | disclosed |
| US-5561145-A | 4-aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESHRANKTER HAFTUNG (DE) | 1996-10-01 | — | — | US | disclosed |
| EP-0635505-A1 | 4-Aryloxy- and 4-arylthiopiperidine derivatives | MERCK PATENT GmbH (DE) | 1995-01-25 | — | — | EP | disclosed |