SCHEMBL6961776

SCHEMBL6961776

C=CCn1c(CCl)nc(C(C)C)c1Sc1cccc([N+](=O)[O-])c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 1/20 0.40
ALDH1A1 P00352 4/20 0.40
GFER P55789 2/20 0.40
IRAK4 Q9NWZ3 1/20 0.40
APOBEC3G Q9HC16 1/20 0.40
MAPT P10636 3/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
CYP3A4 P08684 1/20 0.38
NPC1 O15118 2/20 0.38
POLB P06746 2/20 0.38
RAB9A P51151 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HSP90AA1 P07900 1/20 0.36
TSHR P16473 1/20 0.35
MEN1 O00255 1/20 0.35
PSMD14 O00487 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6976452 0.90 CFTR (0.40) CFTRALDH1A1GFERIRAK4APOBEC3G
SCHEMBL6969470 0.88 HSP90AA1 (0.39) CFTRALDH1A1GFERIRAK4MAPT
SCHEMBL6960458 0.86 IRAK4 (0.39) CFTRALDH1A1GFERIRAK4APOBEC3G
SCHEMBL6962629 0.85 KMT2A (0.42) CFTRALDH1A1MAPTSMN1; SMN2POLB
SCHEMBL6962662 0.84 HSP90AA1 (0.41) ALDH1A1GFERIRAK4MAPTSMN1; SMN2
SCHEMBL6973144 0.84 TSHR (0.35) ALDH1A1APOBEC3GMAPTCYP2C9CYP2C19
SCHEMBL6969208 0.78 HSP90AA1 (0.39) CFTRALDH1A1GFERIRAK4MAPT
SCHEMBL6961422 0.78 HSP90AA1 (0.39) CFTRALDH1A1GFERIRAK4MAPT
SCHEMBL6968955 0.77 MAPT (0.42) CFTRALDH1A1MAPTSMN1; SMN2KMT2A
SCHEMBL8801589 0.77 HSP90AA1 (0.38) ALDH1A1GFERMAPTCYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed