Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6658910 | 0.92 | SMN1; SMN2 (0.46) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6686004 | 0.89 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6656468 | 0.88 | KMT2A (0.45) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6686322 | 0.88 | KMT2A (0.47) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL147709 | 0.87 | AAK1 (0.50) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6654761 | 0.87 | NPSR1 (0.51) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6689185 | 0.86 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6654581 | 0.86 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6658092 | 0.86 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL6661702 | 0.86 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-B1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-5859008-A | Arylalkyl diazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-01-12 | — | — | US | disclosed |
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |