Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.80 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.80 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759169 | 0.89 | STIM1 (0.80) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL715052 | 0.89 | STIM1 (1.00) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL30096538 | 0.89 | STIM1 (1.00) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL756322 | 0.86 | STIM1 (0.86) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL755899 | 0.85 | STIM1 (0.74) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL757813 | 0.85 | STIM1 (0.74) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL758373 | 0.81 | STIM1 (0.68) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL758374 | 0.81 | STIM1 (0.84) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL760683 | 0.79 | STIM1 (0.78) | STIM1ORAI1NPC1RAB9AALDH1A1 | |
| SCHEMBL759947 | 0.79 | STIM1 (0.79) | STIM1ORAI1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421835-A1 | N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS | Glaxo Group Limited (GB) | 2012-02-29 | — | — | EP | disclosed |