Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 17/20 | 1.00 |
| ▸ | DRD2 | P14416 | 15/20 | 1.00 |
| ▸ | DRD3 | P35462 | 11/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | HTR2A | P28223 | 1/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.80 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.80 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.80 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908421 | 0.92 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6906626 | 0.89 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6910062 | 0.89 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6907359 | 0.88 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6909154 | 0.88 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6901807 | 0.85 | DRD4 (0.74) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL16089375 | 0.84 | DRD4 (0.71) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6906064 | 0.84 | DRD4 (0.78) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6906052 | 0.84 | DRD4 (1.00) | DRD4DRD2DRD3HTR1ACHRM5 | |
| SCHEMBL6907908 | 0.83 | DRD4 (0.84) | DRD4DRD2DRD3HTR1ACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906294-B1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-01-29 | — | — | EP | claimed |
| US-6177422-B1 | ANTIPSYCHOTIC AGENT WITH REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | claimed |
| EP-0906294-B1 | BENZOXAZINONE DOPAMINE D4 RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2003-01-29 | — | — | EP | disclosed |
| US-6177422-B1 | ANTIPSYCHOTIC AGENT WITH REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |