⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14243118 | 0.95 | GAA (0.31) | — | |
| SCHEMBL2485471 | 0.92 | USP2 (0.31) | — | |
| SCHEMBL14143534 | 0.92 | USP2 (0.31) | — | |
| SCHEMBL10228721 | 0.89 | — | — | |
| SCHEMBL13762393 | 0.86 | — | — | |
| SCHEMBL1326448 | 0.85 | GAA (0.37) | — | |
| SCHEMBL28508223 | 0.83 | — | — | |
| SCHEMBL11351135 | 0.80 | GAA (0.37) | — | |
| SCHEMBL19321826 | 0.78 | GBA1 (0.32) | — | |
| SCHEMBL20306257 | 0.78 | EPHX1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819670-B1 | 12-ARYL PROSTAGLANDIN ANALOGS | ALLERGAN INC (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2423199-A1 | Substituted imidazoles and their use as pesticides | Pfizer Limited (GB) | 2012-02-29 | — | — | EP | disclosed |
| US-7825149-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20090312326-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-7592362-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-09-22 | — | — | US | disclosed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | disclosed |
| US-7544706-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-09 | — | — | US | disclosed |
| US-20080125473-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080119536-A1 | SUBSTITUTED IMIDAZOLES | PFIZER LIMITED (GB) | 2008-05-22 | — | — | US | disclosed |
| US-20070167506-A1 | SUBSTITUTED IMIDAZOLES | PFIZER INC. (US) | 2007-07-19 | — | — | US | disclosed |
| US-7091231-B2 | 12-Aryl prostaglandin analogs | ALLERGAN, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060148894-A1 | Z)-7-{(1R,2S,3R)-2-[4-(Cyclohexyl-hydroxy-methyl)-phenyl]-3-hydroxy-5-oxo cyclopentyl}-hept-5-enoic acid methyl ester; treating vision defects | ALLERGAN, INC. (US) | 2006-07-06 | — | — | US | disclosed |
| US-4833157-A | ANTIULCER AGENTS | MILES INC. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4742080-A | Therapeutic method for producing bronchodilation by administration of 15-deoxy-16-hydroxy prostaglandin esters | MILES LABORATORIES, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4415592-A | ANTISECRETORY AND HYPOTENSIVE AGENTS | MILES LABORATORIES, INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4331688-A | Therapeutic method for inhibiting gastric secretion by administration of 15-deoxy-16-hydroxy prostaglandins | MILES LABORATORIES, INC. (US) | 1982-05-25 | — | — | US | disclosed |
| US-4275224-A | BRONCHODIALATORS AND ANTI-GASTRIC SECRETION AGENTS | MILES LABORATORIES, INC. (US) | 1981-06-23 | — | — | US | disclosed |
| US-4132738-A | BRONCHODILATORS, ANTISECRETORY AGENTS | MILES LABORATORIES, INC. (US) | 1979-01-02 | — | — | US | disclosed |