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SCHEMBL6963471

SCHEMBL6963471

O=C(O)c1cc(Br)cc(C(=O)C=Cc2cccc(C=Cc3ccc4ccccc4n3)c2)c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CYSLTR1 Q9Y271 19/20 1.00
▸ CYSLTR2 Q9NS75 18/20 1.00
▸ MEN1 O00255 1/20 0.59
▸ ALDH1A1 P00352 1/20 0.59
▸ MAPT P10636 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ L3MBTL1 Q9Y468 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6963468 1.00 CYSLTR1 (1.00) CYSLTR1CYSLTR2MEN1ALDH1A1MAPT
SCHEMBL6964179 0.90 CYSLTR1 (1.00) CYSLTR1CYSLTR2MEN1KMT2A
SCHEMBL6957581 0.90 CYSLTR1 (1.00) CYSLTR1CYSLTR2
SCHEMBL6969952 0.90 CYSLTR2 (1.00) CYSLTR1CYSLTR2
SCHEMBL6964172 0.90 CYSLTR1 (1.00) CYSLTR1CYSLTR2MEN1KMT2A
SCHEMBL6957585 0.90 CYSLTR1 (1.00) CYSLTR1CYSLTR2
SCHEMBL6969950 0.90 CYSLTR2 (1.00) CYSLTR1CYSLTR2
SCHEMBL6964077 0.89 CYSLTR2 (1.00) CYSLTR1CYSLTR2
SCHEMBL6964075 0.89 CYSLTR2 (1.00) CYSLTR1CYSLTR2
SCHEMBL6968948 0.87 CYSLTR2 (1.00) CYSLTR1CYSLTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0902007-B1 CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME KOWA CO (JP) 2003-11-05 — — EP disclosed
EP-0902007-A1 CHALCONE DERIVATIVES AND DRUGS CONTAINING THE SAME KOWA CO. LTD. (JP) 1999-03-17 — — EP disclosed
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